Metabolism and karyotype analysis of oocytes from patients with polycystic ovary syndrome | Zendy

Stephanie E. Harris | Zendy; Deivanayagam Maruthini | Zendy; T. Tang | Zendy; Adam Balen | Zendy; Helen M. Picton | Zendy

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Metabolism and karyotype analysis of oocytes from patients with polycystic ovary syndrome

Author(s) -

Stephanie E. Harris,

Deivanayagam Maruthini,

T. Tang,

Adam Balen,

Helen M. Picton

Publication year - 2010

Publication title -

human reproduction

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.446

H-Index - 226

eISSN - 1460-2350

pISSN - 0268-1161

DOI - 10.1093/humrep/deq181

Subject(s) - polycystic ovary , oocyte , endocrinology , medicine , biology , metformin , anovulation , insulin resistance , insulin , genetics , embryo

Polycystic ovary syndrome (PCOS) is associated with metabolic disturbances which include impaired insulin signalling and glucose metabolism in ovarian follicles. The oocyte is metabolically dependent upon its follicle environment during development, but it is unclear whether PCOS or polycystic ovarian (PCO) morphology alone affect oocyte metabolism and energy-demanding processes such as meiosis.

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