Glial cell line-derived neurotrophic factor is constitutively produced by human testicular peritubular cells and may contribute to the spermatogonial stem cell niche in man | Zendy

Katrin Spinnler | Zendy; F.M. Köhn | Zendy; U. Schwarzer | Zendy; Artur Mayerhofer | Zendy

Open Access

Glial cell line-derived neurotrophic factor is constitutively produced by human testicular peritubular cells and may contribute to the spermatogonial stem cell niche in man

Author(s) -

Katrin Spinnler,

F.M. Köhn,

U. Schwarzer,

Artur Mayerhofer

Publication year - 2010

Publication title -

human reproduction

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.446

H-Index - 226

eISSN - 1460-2350

pISSN - 0268-1161

DOI - 10.1093/humrep/deq170

Subject(s) - glial cell line derived neurotrophic factor , sertoli cell , biology , stem cell factor , neurotrophic factors , spermatogenesis , microbiology and biotechnology , medicine , stem cell , endocrinology , receptor , progenitor cell , biochemistry

Testicular peritubular cells form an ill-characterized cellular compartment of the human testis, which forms a border with Sertoli cells and spermatogonial stem cells (SSCs). A recently developed culture method has identified parts of the secretory repertoire of human testicular peritubular cells (HTPCs), which includes nerve growth factor. Whether peritubular cells produce glial cell line-derived neurotrophic factor (GDNF) and may thus contribute to the stem cell niche is not known.

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