OCT4 expression in human uterine myometrial stem/progenitor cells | Zendy

Masanori Ono | Zendy; Takashi Kajitani | Zendy; Hiroshi Uchida | Zendy; Toru Arase | Zendy; Hideyuki Oda | Zendy; S. Nishikawa-Uchida | Zendy; Hirotaka Masuda | Zendy; Takashi Nagashima | Zendy; Y. Yoshimura | Zendy; Tetsuo Maruyama | Zendy

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OCT4 expression in human uterine myometrial stem/progenitor cells

Author(s) -

Masanori Ono,

Takashi Kajitani,

Hiroshi Uchida,

Toru Arase,

Hideyuki Oda,

S. Nishikawa-Uchida,

Hirotaka Masuda,

Takashi Nagashima,

Y. Yoshimura,

Tetsuo Maruyama

Publication year - 2010

Publication title -

human reproduction

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.446

H-Index - 226

eISSN - 1460-2350

pISSN - 0268-1161

DOI - 10.1093/humrep/deq163

Subject(s) - stem cell , progenitor cell , biology , embryonic stem cell , population , myometrium , microbiology and biotechnology , andrology , endocrinology , medicine , uterus , genetics , gene , environmental health

The transcription factor, octamer-binding transcription factor 4 (OCT4)/POU5F1, is expressed in embryonic stem cells, germ cells and some types of adult stem cells. Human OCT4 encodes two isoforms, OCT4A and OCT4B. While OCT4A plays a crucial role in the maintenance of stem cell properties, including pluripotency, whereas OCT4B does not. We previously reported that human myometrium contains side population cells (myoSP) with a Hoechst 33 342 low-fluorescent profile. These cells exhibit phenotypic and functional characteristics of myometrial stem cells. The objective of this study was to investigate the comparative expression of OCT4 in the stem/progenitor cell population of the human myometrium.

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