Ovarian follicle loss in humans and mice: lessons from statistical model comparison | Zendy

James E. Coxworth | Zendy; Kristen Hawkes | Zendy

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Ovarian follicle loss in humans and mice: lessons from statistical model comparison

Author(s) -

James E. Coxworth,

Kristen Hawkes

Publication year - 2010

Publication title -

human reproduction

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.446

H-Index - 226

eISSN - 1460-2350

pISSN - 0268-1161

DOI - 10.1093/humrep/deq136

Subject(s) - biology , follicular phase , follicle , oocyte , ovarian follicle , population , covariate , fertility , statistics , demography , genetics , endocrinology , mathematics , embryo , sociology

Mammalian oocyte stocks reach maximum size in early development and begin depletion immediately thereafter. This depletion ends women's fertility by midlife. Here we compare five models proposed to characterize human follicular depletion, highlight underlying variation in atresia, and use oocyte counts from laboratory mice to illustrate possible effects of known covariates.

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