Improving FISH diagnosis for preimplantation genetic aneuploidy screening | Zendy

Pere Mir | Zendy; Lorena Rodrigo | Zendy; Emilia Mateu | Zendy; Vanessa Peinado | Zendy; Miguel Milán | Zendy; Amparo Mercader | Zendy; Pilar Buendía | Zendy; A. Delgado | Zendy; António Pellicer | Zendy; J. Remohı́ | Zendy; Carmen Rubio | Zendy

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Improving FISH diagnosis for preimplantation genetic aneuploidy screening

Author(s) -

Pere Mir,

Lorena Rodrigo,

Emilia Mateu,

Vanessa Peinado,

Miguel Milán,

Amparo Mercader,

Pilar Buendía,

A. Delgado,

António Pellicer,

J. Remohı́,

Carmen Rubio

Publication year - 2010

Publication title -

human reproduction

Language(s) - Uncategorized

Resource type - Journals

SCImago Journal Rank - 2.446

H-Index - 226

eISSN - 1460-2350

pISSN - 0268-1161

DOI - 10.1093/humrep/deq122

Subject(s) - aneuploidy , fluorescence in situ hybridization , fish <actinopterygii> , preimplantation genetic diagnosis , biology , comparative genomic hybridization , in situ hybridization , genetics , cytogenetics , chromosome , embryo , gene , fishery , gene expression

In our routine programme of preimplantation genetic aneuploidy screening (PGS) by fluorescence in situ hybridization (FISH), nine chromosomes (13, 15, 16, 17, 18, 21, 22, X and Y) are analysed in two consecutive hybridization rounds. We also perform additional hybridization rounds for these chromosomes, using probes that bind to different loci, for non-conclusive results and for confirmation of certain aneuploidies. The aim of this study was to evaluate the impact of additional hybridization rounds on FISH accuracy.

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