The paternal effect of chromosome translocation carriers observed from meiotic segregation in embryos | Zendy

Belén Lledó | Zendy; J A Ortíz | Zendy; Raúl Juntas Morales | Zendy; José Simó | Zendy; P. E. de la Fuente | Zendy; C. Garcia-Ochoa | Zendy; R. Bernabeu | Zendy

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The paternal effect of chromosome translocation carriers observed from meiotic segregation in embryos

Author(s) -

Belén Lledó,

J A Ortíz,

Raúl Juntas Morales,

José Simó,

P. E. de la Fuente,

C. Garcia-Ochoa,

R. Bernabeu

Publication year - 2010

Publication title -

human reproduction

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.446

H-Index - 226

eISSN - 1460-2350

pISSN - 0268-1161

DOI - 10.1093/humrep/deq111

Subject(s) - chromosomal translocation , meiosis , biology , preimplantation genetic diagnosis , embryo , andrology , genetics , chromosome , chromosome segregation , gene , medicine

Human translocation carriers may present alterations in meiosis. Understanding the mechanism of meiotic segregation of reciprocal translocations is important for estimation of the risk of either pregnancy loss or birth defects. The objective of this work was to estimate meiotic segregation rates in preimplantation embryos from preimplantation genetic diagnosis (PGD) cycles of female and male reciprocal translocation carriers.

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