Predictive value of sperm-FISH analysis on the outcome of preimplantation genetic diagnosis (PGD) for a pericentric inversion inv5(p15.3q11.2) carrier | Zendy

Izabel Bernicot | Zendy; C. Dechanet | Zendy; A. Mace | Zendy; B. Hédon | Zendy; S. Hamamah | Zendy; Franck Pellestor | Zendy; T. Anahory | Zendy

Open Access

Predictive value of sperm-FISH analysis on the outcome of preimplantation genetic diagnosis (PGD) for a pericentric inversion inv5(p15.3q11.2) carrier

Author(s) -

Izabel Bernicot,

C. Dechanet,

A. Mace,

B. Hédon,

S. Hamamah,

Franck Pellestor,

T. Anahory

Publication year - 2010

Publication title -

human reproduction

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.446

H-Index - 226

eISSN - 1460-2350

pISSN - 0268-1161

DOI - 10.1093/humrep/deq101

Subject(s) - preimplantation genetic diagnosis , chromosomal inversion , sperm , predictive value , andrology , biology , gynecology , genetics , medicine , embryo , karyotype , gene , chromosome

Pericentric inversions (PIs) are structural chromosomal abnormalities, potentially associated with infertility or multiple miscarriages. More rarely, at meiosis, odd numbers of genetic recombinations within the inversion loop produce recombinant gametes which may lead to aneusomy of recombination in the offspring.

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