Activin A regulates trophoblast cell adhesive properties: implications for implantation failure in women with endometriosis-associated infertility | Zendy

C. Stoikos | Zendy; Lois A. Salamonsen | Zendy; Natalie J. Hannan | Zendy; Anne E. O′Connor | Zendy; Luk Rombauts | Zendy; Evdokia Dimitriadis | Zendy

Open Access

Activin A regulates trophoblast cell adhesive properties: implications for implantation failure in women with endometriosis-associated infertility

Author(s) -

C. Stoikos,

Lois A. Salamonsen,

Natalie J. Hannan,

Anne E. O′Connor,

Luk Rombauts,

Evdokia Dimitriadis

Publication year - 2010

Publication title -

human reproduction

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.446

H-Index - 226

eISSN - 1460-2350

pISSN - 0268-1161

DOI - 10.1093/humrep/deq097

Subject(s) - implantation failure , endometriosis , infertility , trophoblast , medicine , gynecology , andrology , endocrinology , pregnancy , biology , placenta , fetus , genetics

During implantation, the embryo adheres to the endometrium via cell adhesion molecules (CAMs) present on blastocyst trophectoderm and endometrial epithelial cells. CAMs, including integrins and extracellular matrix (ECM) ligands, are most likely regulated by hormones, cytokines and growth factors. We hypothesized first that activin A affects the adhesive properties of trophoblast cells and second that alterations in dimeric activin A levels in the uterine cavity could disrupt adhesion, thereby causing implantation failure.

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