Proteins from human oviductal tissue-conditioned medium modulate sperm capacitation | Zendy

Carlos Zumoffen | Zendy; Adriana M. Caille | Zendy; María José Munuce | Zendy; Marcelo O. Cabada | Zendy; Sergio Ghersevich | Zendy

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Proteins from human oviductal tissue-conditioned medium modulate sperm capacitation

Author(s) -

Carlos Zumoffen,

Adriana M. Caille,

María José Munuce,

Marcelo O. Cabada,

Sergio Ghersevich

Publication year - 2010

Publication title -

human reproduction

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.446

H-Index - 226

eISSN - 1460-2350

pISSN - 0268-1161

DOI - 10.1093/humrep/deq063

Subject(s) - capacitation , sperm , andrology , tyrosine phosphorylation , acrosome reaction , zona pellucida , biology , oocyte , incubation , human fertilization , semen , microbiology and biotechnology , phosphorylation , embryo , anatomy , biochemistry , medicine

Spermatozoa acquire the ability to fertilize an oocyte when they become capacitated. Capacitation takes place when sperm pass through the female reproductive tract, interacting with female fluids. Both tyrosine phosphorylation of sperm proteins and the ability to respond to acrosome reaction (AR) inducers have been associated with sperm capacitation. Recent data indicate that conditioned media (CM) from human oviductal tissue culture decrease sperm affinity for the zona pellucida in vitro. Since capacitation enables the sperm-oocyte interaction, the aim of the present study was to investigate the effect of CM on events related to sperm capacitation and to assess whether these effects were permanent.

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