The risk of post-molar gestational trophoblastic neoplasia is higher in heterozygous than in homozygous complete hydatidiform moles | Zendy

B. Baasanjav | Zendy; Hirokazu Usui | Zendy; Maki Kihara | Zendy; Hiroshi Kaku | Zendy; Emiri Nakada | Zendy; Shinichi Tate | Zendy; Akira Mitsuhashi | Zendy; Hideo Matsui | Zendy; Makio Shozu | Zendy

Open Access

The risk of post-molar gestational trophoblastic neoplasia is higher in heterozygous than in homozygous complete hydatidiform moles

Author(s) -

B. Baasanjav,

Hirokazu Usui,

Maki Kihara,

Hiroshi Kaku,

Emiri Nakada,

Shinichi Tate,

Akira Mitsuhashi,

Hideo Matsui,

Makio Shozu

Publication year - 2010

Publication title -

human reproduction

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.446

H-Index - 226

eISSN - 1460-2350

pISSN - 0268-1161

DOI - 10.1093/humrep/deq052

Subject(s) - gestational trophoblastic neoplasia , molar pregnancy , molar , mole , medicine , obstetrics , gestation , gynecology , pregnancy , choriocarcinoma , biology , genetics , dentistry

Complete hydatidiform mole (CHM) is a high-risk pregnancy for gestational trophoblastic neoplasia (GTN). Patients with CHM have a 10-30% chance of trophoblastic sequelae. CHM includes androgenic homozygous (monospermic) and androgenic heterozygous (dispermic) moles. It is controversial whether the risk of GTN is higher with heterozygous than with homozygous CHM. A prospective cohort study was conducted to assess risk of GTN in homozygous and heterozygous CHM using short tandem repeat (STR) polymorphisms, and a meta-analysis of previous reports.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research