Identification of the G994T polymorphism in exon 9 of plasma platelet-activating factor acetylhydrolase gene as a risk factor for polycystic ovary syndrome | Zendy

Ping Fan | Zendy; Hongwei Liu | Zendy; Xiaosu Wang | Zendy; Feng Zhang | Zendy; Qi Song | Zendy; Qin Li | Zendy; Hongmei Wu | Zendy; Huai Bai | Zendy

Open Access

Identification of the G994T polymorphism in exon 9 of plasma platelet-activating factor acetylhydrolase gene as a risk factor for polycystic ovary syndrome

Author(s) -

Ping Fan,

Hongwei Liu,

Xiaosu Wang,

Feng Zhang,

Qi Song,

Qin Li,

Hongmei Wu,

Huai Bai

Publication year - 2010

Publication title -

human reproduction

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.446

H-Index - 226

eISSN - 1460-2350

pISSN - 0268-1161

DOI - 10.1093/humrep/deq047

Subject(s) - medicine , endocrinology , polycystic ovary , genotype , biology , insulin resistance , insulin , gene , genetics

Low-grade chronic inflammation and greater risks of cardiovascular diseases are often present in patients with polycystic ovary syndrome (PCOS). Platelet-activating factor (PAF) acetylhydrolase (PAF-AH) hydrolyzes and inactivates PAF and PAF-like oxidized phospholipids that are potent lipid mediators involved in inflammation and atherosclerosis. Deficiency of this enzyme is caused by a missense mutation (G994 --> T) in exon 9 of the plasma PAF-AH gene. The aim of the study was to investigate a possible association of this polymorphism with the risk of PCOS and to evaluate the effects of the genotype on the activity and distribution of PAFAH in Chinese patients.

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