Open AccessThe first woman to give birth to two children following transplantation of frozen/thawed ovarian tissue
Author(s) -
E. Ernst,
Stinne Holm Bergholdt,
Jan Stener Jørgensen,
Claus Yding Andersen
Publication year - 2010
Publication title -
human reproduction
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.446
H-Index - 226
eISSN - 1460-2350
pISSN - 0268-1161
DOI - 10.1093/humrep/deq033
Subject(s) - ovarian tissue cryopreservation , cryopreservation , ovarian cortex , transplantation , girl , fertility preservation , medicine , ovarian tissue , fertility , embryo cryopreservation , live birth , ovary , gynecology , pregnancy , surgery , biology , embryo , endocrinology , population , genetics , environmental health , microbiology and biotechnology
Worldwide eight children have been born as a result of transplanting frozen/thawed ovarian tissue. Two of these children were born in Denmark following transport of the ovarian tissue for a period of 5 h prior to cryopreservation. One of these women, who was originally transplanted with six pieces of ovarian cortex, after having experienced a period of menopause has now conceived again following natural conception. She gave birth to a healthy girl on 23 September 2008 and is therefore the first woman in the world to have had two children, from separate pregnancies, born as a result of transplanting frozen/thawed ovarian tissue. This result encourages further development of cryopreservation of ovarian tissue for fertility preservation as a clinical procedure for girls and young women facing gonadotoxic treatment.
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