Vitamin D receptor and vitamin D metabolizing enzymes are expressed in the human male reproductive tract | Zendy

Martin Blomberg Jensen | Zendy; Jens Høiriis Nielsen | Zendy; Anne Jørgensen | Zendy; Ewa RajpertDe Meyts | Zendy; David M. Kristensen | Zendy; Niels Jørgensen | Zendy; Niels E. Skakkebæk | Zendy; Anders Juul | Zendy; Henrik Leffers | Zendy

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Vitamin D receptor and vitamin D metabolizing enzymes are expressed in the human male reproductive tract

Author(s) -

Martin Blomberg Jensen,

Jens Høiriis Nielsen,

Anne Jørgensen,

Ewa RajpertDe Meyts,

David M. Kristensen,

Niels Jørgensen,

Niels E. Skakkebæk,

Anders Juul,

Henrik Leffers

Publication year - 2010

Publication title -

human reproduction

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.446

H-Index - 226

eISSN - 1460-2350

pISSN - 0268-1161

DOI - 10.1093/humrep/deq024

Subject(s) - calcitriol receptor , epididymis , cyp24a1 , biology , endocrinology , medicine , seminal vesicle , sperm , spermatogenesis , prostate , vitamin d and neurology , semen , andrology , anatomy , botany , cancer

The vitamin D receptor (VDR) is expressed in human testis, and vitamin D (VD) has been suggested to affect survival and function of mature spermatozoa. Indeed, VDR knockout mice and VD deficient rats show decreased sperm counts and low fertility. However, the cellular response to VD is complex, since it is not solely dependent on VDR expression, but also on cellular uptake of circulating VD and presence and activity of VD metabolizing enzymes. Expression of VD metabolizing enzymes has not previously been investigated in human testis and male reproductive tract. Therefore, we performed a comprehensive analysis of the expression of VDR, VD activating (CYP2R1, CYP27A1, CYP27B1) and inactivating (CYP24A1) enzymes in the testis, epididymis, seminal vesicle (SV), prostate and spermatozoa.

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