Systemic and local effects of metformin administration in patients with polycystic ovary syndrome (PCOS): relationship to the ovulatory response | Zendy

Stefano Palomba | Zendy; Angela Falbo | Zendy; Tiziana Russo | Zendy; Francesco Orio | Zendy; Achille Tolino | Zendy; Fulvio Zullo | Zendy

Open Access

Systemic and local effects of metformin administration in patients with polycystic ovary syndrome (PCOS): relationship to the ovulatory response

Author(s) -

Stefano Palomba,

Angela Falbo,

Tiziana Russo,

Francesco Orio,

Achille Tolino,

Fulvio Zullo

Publication year - 2010

Publication title -

human reproduction

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.446

H-Index - 226

eISSN - 1460-2350

pISSN - 0268-1161

DOI - 10.1093/humrep/dep466

Subject(s) - polycystic ovary , metformin , medicine , ovulation , anovulation , insulin resistance , antral follicle , follicular phase , endocrinology , hormone , insulin

Several data have demonstrated the efficacy of metformin in inducing ovulation in patients with polycystic ovary syndrome (PCOS), however, the exact mechanism by which this drug acts remains unknown. The aim of the present study was to evaluate whether the efficacy of the drug in patients with PCOS is related to a systemic hormonal-metabolic improvement, or to a local action on the ovary.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research