Open AccessFlexible GnRH antagonist protocol versus GnRH agonist long protocol in patients with polycystic ovary syndrome treated for IVF: a prospective randomised controlled trial (RCT)
Author(s) -
Trifon G. Lainas,
Ioannis A. Sfontouris,
Ioannis Z. Zorzovilis,
George K. Petsas,
George T. Lainas,
Efthymia Alexopoulou,
Efstratios M. Κolibianakis
Publication year - 2009
Publication title -
human reproduction
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.446
H-Index - 226
eISSN - 1460-2350
pISSN - 0268-1161
DOI - 10.1093/humrep/dep436
Subject(s) - ovarian hyperstimulation syndrome , polycystic ovary , medicine , gonadotropin releasing hormone antagonist , randomized controlled trial , agonist , antagonist , pregnancy rate , gynecology , in vitro fertilisation , endocrinology , gonadotropin releasing hormone , pregnancy , biology , hormone , luteinizing hormone , insulin resistance , genetics , receptor , insulin
Women with polycystic ovary syndrome (PCOS) are at risk of developing ovarian hyperstimulation syndrome (OHSS) during ovarian stimulation. Use of GnRH antagonist in the general subfertile population is associated with lower incidence of OHSS than agonists and similar probability of live birth but it is unclear if this is true for patients with PCOS. Our aim was to compare the flexible GnRH antagonist and GnRH agonist long protocols in patients with PCOS undergoing IVF (primary end-point: ongoing pregnancy rate per patient randomized).
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