A reduced size of the ovarian follicle pool is associated with an increased risk of a trisomic pregnancy in IVF-treated women | Zendy

M.L. Haadsma | Zendy; Thea M. Mooij | Zendy; Henk Groen | Zendy; Curt W. Burger | Zendy; Cornelis B. Lambalk | Zendy; Frank J. Broekmans | Zendy; Flora E. van Leeuwen | Zendy; K. Bouman | Zendy; Annemieke Hoek | Zendy

Open Access

A reduced size of the ovarian follicle pool is associated with an increased risk of a trisomic pregnancy in IVF-treated women

Author(s) -

M.L. Haadsma,

Thea M. Mooij,

Henk Groen,

Curt W. Burger,

Cornelis B. Lambalk,

Frank J. Broekmans,

Flora E. van Leeuwen,

K. Bouman,

Annemieke Hoek

Publication year - 2009

Publication title -

human reproduction

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.446

H-Index - 226

eISSN - 1460-2350

pISSN - 0268-1161

DOI - 10.1093/humrep/dep404

Subject(s) - trisomy , pregnancy , odds ratio , gynecology , in vitro fertilisation , obstetrics , ovarian hyperstimulation syndrome , medicine , ovarian reserve , confidence interval , oocyte , pregnancy rate , menopause , down syndrome , biology , infertility , endocrinology , embryo , genetics , psychiatry

The increased risk of a trisomic pregnancy with a woman's age arises from an increased rate of meiotic non-disjunction in the oocytes. It has been hypothesized that the increase in meiotic errors is related to the decreasing number of oocytes with age. Our aim was to assess the relation between trisomic pregnancy and three parameters of oocyte quantity.

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