Insulin resistance and free androgen index correlate with the outcome of controlled ovarian hyperstimulation in non-PCOS women undergoing IVF | Zendy

Emily H Dickerson | Zendy; L.W. Cho | Zendy; S.D. Maguiness | Zendy; S.L. Killick | Zendy; J. Elliott Robinson | Zendy; Stephen L. Atkin | Zendy

Open Access

Insulin resistance and free androgen index correlate with the outcome of controlled ovarian hyperstimulation in non-PCOS women undergoing IVF

Author(s) -

Emily H Dickerson,

L.W. Cho,

S.D. Maguiness,

S.L. Killick,

J. Elliott Robinson,

Stephen L. Atkin

Publication year - 2009

Publication title -

human reproduction

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.446

H-Index - 226

eISSN - 1460-2350

pISSN - 0268-1161

DOI - 10.1093/humrep/dep393

Subject(s) - polycystic ovary , endocrinology , medicine , context (archaeology) , androgen , insulin resistance , antral follicle , free androgen index , folliculogenesis , hyperandrogenism , follicular phase , insulin , biology , hormone , pregnancy , paleontology , genetics , lactation

The dual effects of insulin and androgen on the ovary act to promote early folliculogenesis. In the context of polycystic ovarian syndrome (PCOS), the presence of hyperinsulinaemia, resulting from increased insulin resistance (IR), and hyperandrogenaemia lead to the appearance of multiple antral follicles and frequently a multi-follicular response to gonadotrophin stimulation for assisted reproductive treatments (ARTs). The effect of IR and androgen status in women without PCOS on the follicular outcome of controlled ovarian hyperstimulation (COH) is not known.

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