Induction of a local pseudo-pregnancy via levonorgestrel-loaded microspheres for the treatment of endometriosis in a rabbit model | Zendy

Peng Yuan | Zendy; Yanhong Huang | Zendy; Hao Wu | Zendy; Zhongzhao Teng | Zendy; Jiawei Zhang | Zendy; Xiaoyan Xin | Zendy

Open Access

Induction of a local pseudo-pregnancy via levonorgestrel-loaded microspheres for the treatment of endometriosis in a rabbit model

Author(s) -

Peng Yuan,

Yanhong Huang,

Hao Wu,

Zhongzhao Teng,

Jiawei Zhang,

Xiaoyan Xin

Publication year - 2009

Publication title -

human reproduction

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.446

H-Index - 226

eISSN - 1460-2350

pISSN - 0268-1161

DOI - 10.1093/humrep/dep386

Subject(s) - endometriosis , pregnancy , levonorgestrel , medicine , obstetrics , gynecology , population , family planning , biology , research methodology , genetics , environmental health

Endometriosis is a chronic disease that responds to systemic pseudo-pregnancy therapy. However, side effects limit their long-term use, and recurrence often occurs after cessation of medication. Reducing side effects whereas improving therapeutic efficacy of pseudo-pregnancy therapy seems contradictory, but appealing. In order to address this dilemma, the efficacy and side effects of local pseudo-pregnancy therapy were investigated for the first time in an endometriosis animal model.

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