Inhibition of proteases involved in embryo implantation by cholesterol sulfate | Zendy

Minako Koizumi | Zendy; Mikio Momoeda | Zendy; Hisahiko Hiroi | Zendy; Fumiko Nakazawa | Zendy; Hajime Nakae | Zendy; Tomoko Ohno | Zendy; T. Yano | Zendy; Y. Taketani | Zendy

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Inhibition of proteases involved in embryo implantation by cholesterol sulfate

Author(s) -

Minako Koizumi,

Mikio Momoeda,

Hisahiko Hiroi,

Fumiko Nakazawa,

Hajime Nakae,

Tomoko Ohno,

T. Yano,

Y. Taketani

Publication year - 2009

Publication title -

human reproduction

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.446

H-Index - 226

eISSN - 1460-2350

pISSN - 0268-1161

DOI - 10.1093/humrep/dep370

Subject(s) - plasmin , proteases , matrix metalloproteinase , plasminogen activator , trophoblast , zymography , biochemistry , microbiology and biotechnology , stromal cell , chemistry , western blot , biology , enzyme , placenta , endocrinology , fetus , cancer research , pregnancy , genetics , gene

Matrix metalloproteinases (MMPs) and the plasminogen activator (PA)/plasmin system are two major groups of proteases involved in the matrix degradation required for embryo implantation. We previously showed that the content of cholesterol sulfate (CS) in rabbit endometrium increases characteristically during the implantation period. Furthermore, CS has been reported to inhibit serine proteases. In this study, we investigated whether CS can regulate the activity of proteases in cultured human endometrial stromal cells.

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