Cytogenetic analyses of human oocytes provide new data on non-disjunction mechanisms and the origin of trisomy 16 | Zendy

Raquel Garcia-Cruz | Zendy; A Casanovas | Zendy; Miguel A. BrieñoEnríquez | Zendy; Pedro Robles | Zendy; Ignasi Roig | Zendy; A Pujol | Zendy; L. Cabero | Zendy; Mercè Durban | Zendy; M. Garcı́a | Zendy

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Cytogenetic analyses of human oocytes provide new data on non-disjunction mechanisms and the origin of trisomy 16

Author(s) -

Raquel Garcia-Cruz,

A Casanovas,

Miguel A. BrieñoEnríquez,

Pedro Robles,

Ignasi Roig,

A Pujol,

L. Cabero,

Mercè Durban,

M. Garcı́a

Publication year - 2009

Publication title -

human reproduction

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.446

H-Index - 226

eISSN - 1460-2350

pISSN - 0268-1161

DOI - 10.1093/humrep/dep347

Subject(s) - aneuploidy , trisomy , meiosis , biology , genetics , oocyte , embryo , andrology , chromosome , medicine , gene

Nowadays, oocyte donation is an extended practise in IVF programmes. However, to date, little information on aneuploidy frequency in oocytes from donors is available. Aneuploidy is one of the major causes of embryo and fetal wastage as well as of congenital mental and developmental disabilities. It is known that most aneuploidies are due to non-disjunction events occurring in the maternal germ line. Linkage studies have associated abnormal patterns of meiotic recombination to the origin of the non-disjunction event in many aneuploid conditions.

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