Human decidual stromal cells suppress cytokine secretion by allogenic CD4+ T cells via PD-1 ligand interactions | Zendy

Takeshi Nagamatsu | Zendy; Danny J. Schust | Zendy; Jun Sugimoto | Zendy; Breton F. Barrier | Zendy

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Human decidual stromal cells suppress cytokine secretion by allogenic CD4+ T cells via PD-1 ligand interactions

Author(s) -

Takeshi Nagamatsu,

Danny J. Schust,

Jun Sugimoto,

Breton F. Barrier

Publication year - 2009

Publication title -

human reproduction

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.446

H-Index - 226

eISSN - 1460-2350

pISSN - 0268-1161

DOI - 10.1093/humrep/dep308

Subject(s) - t cell , cytokine , antigen presenting cell , microbiology and biotechnology , stromal cell , biology , immunology , immune system , cancer research

Although previous reports suggest an antigen-presenting function for decidual stromal cells (DSCs), the relevance of cell-to-cell communication between DSCs and T cells at the human feto-maternal interface has not been fully elucidated. Therefore, we investigated the presence and function of human DSC-expressed B7-H1 and B7-DC co-stimulatory ligands. B7-H1 and B7-DC on peripheral antigen-presenting cells (APC) typically inhibit T cell activation after binding to their corresponding receptor, programmed death-1 (PD-1).

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