Longer CAG repeat length in the androgen receptor gene is associated with premature ovarian failure | Zendy

Suparna Chatterjee | Zendy; Singh Rajender | Zendy; Sandeep Kadam | Zendy; Anurupa Maitra | Zendy; Kumarasamy Thangaraj | Zendy; Pervin Meherji | Zendy; Deepak Modi | Zendy

AI Assistant Blog Pricing

Home ZAIA Blog

Open Access

Longer CAG repeat length in the androgen receptor gene is associated with premature ovarian failure

Author(s) -

Suparna Chatterjee,

Singh Rajender,

Sandeep Kadam,

Anurupa Maitra,

Kumarasamy Thangaraj,

Pervin Meherji,

Deepak Modi

Publication year - 2009

Publication title -

human reproduction

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.446

H-Index - 226

eISSN - 1460-2350

pISSN - 0268-1161

DOI - 10.1093/humrep/dep296

Subject(s) - premature ovarian failure , androgen receptor , exon , biology , ovulation , medicine , gene , endocrinology , androgen , phenotype , genetics , hormone , prostate cancer , cancer

Premature ovarian failure (POF) is a disorder characterized by lack of ovulation and elevated serum gonadotrophin levels before the age of 40 years. The cause of POF in most cases is unknown. As mice lacking the Androgen receptor (Ar) gene reportedly have a POF-like phenotype, we hypothesize that, variations in the AR gene maybe one of the causative factors for POF in humans. Thus the objective of the study is to evaluate the number of CAG repeats in exon 1 of the AR gene in non-familial, non-syndromic cases of POF.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research