Cryopreservation-induced human sperm DNA damage is predominantly mediated by oxidative stress rather than apoptosis | Zendy

Laura Kelly Thomson | Zendy; Steven D. Fleming | Zendy; R. John Aitken | Zendy; Geoffry N. De Iuliis | Zendy; Julie-Anne Zieschang | Zendy; Anne Clark | Zendy

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Cryopreservation-induced human sperm DNA damage is predominantly mediated by oxidative stress rather than apoptosis

Author(s) -

Laura Kelly Thomson,

Steven D. Fleming,

R. John Aitken,

Geoffry N. De Iuliis,

Julie-Anne Zieschang,

Anne Clark

Publication year - 2009

Publication title -

human reproduction

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.446

H-Index - 226

eISSN - 1460-2350

pISSN - 0268-1161

DOI - 10.1093/humrep/dep214

Subject(s) - dna fragmentation , oxidative stress , cryopreservation , andrology , apoptosis , sperm , dna damage , biology , fragmentation (computing) , semen , genistein , apoptotic dna fragmentation , cryoprotectant , caspase 3 , microbiology and biotechnology , programmed cell death , biochemistry , dna , genetics , embryo , medicine , ecology

Whereas studies have revealed that the cryopreservation of human semen increases sperm DNA fragmentation, the mechanisms involved in this type of cryo-injury are largely unknown. Elucidation of these mechanisms may provide insight into preventing such injury.

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