MTHFR promoter hypermethylation in testicular biopsies of patients with non-obstructive azoospermia: the role of epigenetics in male infertility | Zendy

N Khazamipour | Zendy; Mehrdad Noruzinia | Zendy; P Fatehmanesh | Zendy; Mousa Keyhanee | Zendy; Pascal Pujol | Zendy

Open Access

MTHFR promoter hypermethylation in testicular biopsies of patients with non-obstructive azoospermia: the role of epigenetics in male infertility

Author(s) -

N Khazamipour,

Mehrdad Noruzinia,

P Fatehmanesh,

Mousa Keyhanee,

Pascal Pujol

Publication year - 2009

Publication title -

human reproduction

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.446

H-Index - 226

eISSN - 1460-2350

pISSN - 0268-1161

DOI - 10.1093/humrep/dep194

Subject(s) - azoospermia , methylenetetrahydrofolate reductase , obstructive azoospermia , methylation , male infertility , dna methylation , epigenetics , cpg site , infertility , testicular sperm extraction , biology , oligospermia , andrology , spermatogenesis , medicine , genetics , gene , pregnancy , allele , gene expression

The causative mechanisms of male infertility are still poorly understood. Mutations in the Methylenetetrahydrofolate reductase (MTHFR) gene have been shown to be involved in male infertility; however, other mechanisms of pathogenesis, like promoter hyper-methylation, could also play a role. Therefore, in this study we compared the methylation status of the promoter region of MTHFR in male patients with non-obstructive azoospermia (NOA) and obstructive azoospermia without anomalies of spermatogenesis.

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