Interleukin 1 regulates its own receptors in human endometrial cells via distinct mechanisms | Zendy

Christian R. Bellehumeur | Zendy; Jean-Paul Blanchet | Zendy; JeanYves Fontaine | Zendy; Nathalie Bourcier | Zendy; Ali Akoum | Zendy

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Interleukin 1 regulates its own receptors in human endometrial cells via distinct mechanisms

Author(s) -

Christian R. Bellehumeur,

Jean-Paul Blanchet,

JeanYves Fontaine,

Nathalie Bourcier,

Ali Akoum

Publication year - 2009

Publication title -

human reproduction

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.446

H-Index - 226

eISSN - 1460-2350

pISSN - 0268-1161

DOI - 10.1093/humrep/dep192

Subject(s) - interleukin 1 receptor, type ii , interleukin 1 receptor, type i , endometrium , interleukin 1 receptor antagonist , receptor , biology , microbiology and biotechnology , receptor antagonist , endocrinology , medicine , signal transduction , cytokine , interleukin , antagonist , immunology , interleukin 5

Interleukin 1 (IL1) plays an important role in the physiology of human endometrium and is recognized as a major and early embryonic signal. Tight control over the local endometrial action of this cytokine is critical for normal reproductive functions. The coordinated regulation of IL1 receptors types I and II (IL1R1 and IL1R2) and IL1 receptor antagonist (IL1RA) in endometrial cells may represent one of the principle mechanisms involved in the control of IL1 local effects. The objective of this study was to investigate the regulation of IL1Rs in human endometrial epithelial cells in response to IL1.

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