Effects of gonadotrophin releasing hormone analogues on human endometrial stromal cells and embryo invasion in vitro | Zendy

Petra Klemmt | Zendy; Fang Liu | Zendy; J. G. Carver | Zendy; Céline Jones | Zendy; DM Brosi | Zendy; J W Adamson | Zendy; Helen J. Mardon | Zendy; Enda McVeigh | Zendy

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Effects of gonadotrophin releasing hormone analogues on human endometrial stromal cells and embryo invasion in vitro

Author(s) -

Petra Klemmt,

Fang Liu,

J. G. Carver,

Céline Jones,

DM Brosi,

J W Adamson,

Helen J. Mardon,

Enda McVeigh

Publication year - 2009

Publication title -

human reproduction

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.446

H-Index - 226

eISSN - 1460-2350

pISSN - 0268-1161

DOI - 10.1093/humrep/dep181

Subject(s) - stromal cell , in vitro , embryo , biology , hormone , endometrium , endocrinology , medicine , andrology , microbiology and biotechnology , cancer research , genetics

Gonadotrophin releasing hormone (GnRH) analogues are widely used in IVF programmes as a method of suppressing the luteinizing hormone (LH) surge prior to ovarian stimulation, but their roles outside the pituitary remain relatively unknown. A 2002 Cochrane review (Al-Inany et al. Gonadotrophin-releasing hormone antagonists for assisted conception. Cochrane Database Syst Rev 2006;3:CD001750) described lower pregnancy rates in women administered with GnRH antagonist, compared with those using an agonist, as part of an IVF programme, despite the fact that GnRH antagonist is a more effective repressor of LH. This study aimed to analyse the in-vitro effects of GnRH analogues on the decidualizing endometrium, blastocyst invasion and GnRH receptor expression in fertile women.

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