Mifepristone acts as progesterone antagonist of non-genomic responses but inhibits phytohemagglutinin-induced proliferation in human T cells | Zendy

C-H Chien | Zendy; JungNien Lai | Zendy; ChingFong Liao | Zendy; O.Y. Wang | Zendy; L.M. Lu | Zendy; MeiLing Huang | Zendy; W.F. Lee | Zendy; MeiChi Shie | Zendy; Eileen Jea Chien | Zendy

Open Access

Mifepristone acts as progesterone antagonist of non-genomic responses but inhibits phytohemagglutinin-induced proliferation in human T cells

Author(s) -

C-H Chien,

JungNien Lai,

ChingFong Liao,

O.Y. Wang,

L.M. Lu,

MeiLing Huang,

W.F. Lee,

MeiChi Shie,

Eileen Jea Chien

Publication year - 2009

Publication title -

human reproduction

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.446

H-Index - 226

eISSN - 1460-2350

pISSN - 0268-1161

DOI - 10.1093/humrep/dep099

Subject(s) - mifepristone , progesterone receptor , endocrinology , medicine , antagonist , intracellular , agonist , receptor , stimulation , biology , cell growth , endogeny , microbiology and biotechnology , pregnancy , biochemistry , genetics , cancer , estrogen receptor , breast cancer

Progesterone is an endogenous immunomodulator that suppresses T cell activation during pregnancy. The stimulation of membrane progesterone receptors (mPRs) would seem to be the cause of rapid non-genomic responses in human peripheral T cells, such as an elevation of intracellular calcium ([Ca(2+)](i)) and decreased intracellular pH (pH(i)). Mifepristone (RU486) produces mixed agonist/antagonist effects on immune cells compared with progesterone. We explored whether RU486 is an antagonist to mPRs and can block rapid non-genomic responses and the induction by phytohemagglutinin (PHA) of cell proliferation.

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