Pregnancies conceived using assisted reproductive technologies (ART) have low levels of pregnancy-associated plasma protein-A (PAPP-A) leading to a high rate of false-positive results in first trimester screening for Down syndrome | Zendy

David J. Amor | Zendy; Juanjuan Xu | Zendy; J. Halliday | Zendy; Ivan Francis | Zendy; D. Healy | Zendy; Sue Breheny | Zendy; H.W.G. Baker | Zendy; AM Jaques | Zendy

Open Access

Pregnancies conceived using assisted reproductive technologies (ART) have low levels of pregnancy-associated plasma protein-A (PAPP-A) leading to a high rate of false-positive results in first trimester screening for Down syndrome

Author(s) -

David J. Amor,

Juanjuan Xu,

J. Halliday,

Ivan Francis,

D. Healy,

Sue Breheny,

H.W.G. Baker,

AM Jaques

Publication year - 2009

Publication title -

human reproduction

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.446

H-Index - 226

eISSN - 1460-2350

pISSN - 0268-1161

DOI - 10.1093/humrep/dep046

Subject(s) - amniocentesis , assisted reproductive technology , medicine , obstetrics , pregnancy associated plasma protein a , chorionic villus sampling , pregnancy , odds ratio , gynecology , first trimester , live birth , spontaneous conception , reproductive technology , nuchal translucency , gestation , fetus , prenatal diagnosis , biology , in vitro fertilisation , infertility , genetics , lactation

First trimester screening (FTS) for Down syndrome combines measurement of nuchal translucency, free beta-human chorionic gonadotrophin and pregnancy-associated plasma protein-A (PAPP-A). The aim of this study was to undertake a detailed analysis of FTS results in singleton pregnancies conceived using assisted reproductive technologies (ART) and non-ART pregnancies.

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