Soluble HLA-G regulates motility and invasion of the trophoblast-derived cell line SGHPL-4 | Zendy

James A. McCormick | Zendy; Guy Whitley | Zendy; Philippe Le Bouteiller | Zendy; Judith E. Cartwright | Zendy

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Soluble HLA-G regulates motility and invasion of the trophoblast-derived cell line SGHPL-4

Author(s) -

James A. McCormick,

Guy Whitley,

Philippe Le Bouteiller,

Judith E. Cartwright

Publication year - 2009

Publication title -

human reproduction

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.446

H-Index - 226

eISSN - 1460-2350

pISSN - 0268-1161

DOI - 10.1093/humrep/dep026

Subject(s) - motility , trophoblast , biology , autocrine signalling , hepatocyte growth factor , microbiology and biotechnology , epidermal growth factor , cell culture , growth factor , apoptosis , stimulation , endocrinology , receptor , fetus , placenta , pregnancy , biochemistry , genetics

Soluble human leucocyte antigen-G (sHLA-G) is secreted by extravillous trophoblast (EVT) and has roles in regulating immune cells within the decidua. HLA-G expression on EVT increases as they approach uterine spiral arteries and we have suggested that sHLA-G may be important in the remodelling of these vessels. The autocrine role of sHLA-G in regulating trophoblast function at this critical phase has not been studied. We aimed to investigate the effects of sHLA-G on trophoblast motility, invasion and survival.

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