Phosphatidylinositol 3-kinase p85 regulatory subunit gene Met326Ile polymorphism in women with polycystic ovary syndrome | Zendy

Jinju Kim | Zendy; Y. M. Choi | Zendy; Min Hong | Zendy; Seung-Sik Hwang | Zendy; Sang Ho Yoon | Zendy; Soo Jin Chae | Zendy; Byung Chul Jee | Zendy; SeungYup Ku | Zendy; J. G. Kim | Zendy; S.Y. Moon | Zendy

Open Access

Phosphatidylinositol 3-kinase p85 regulatory subunit gene Met326Ile polymorphism in women with polycystic ovary syndrome

Author(s) -

Jinju Kim,

Y. M. Choi,

Min Hong,

Seung-Sik Hwang,

Sang Ho Yoon,

Soo Jin Chae,

Byung Chul Jee,

SeungYup Ku,

J. G. Kim,

S.Y. Moon

Publication year - 2009

Publication title -

human reproduction

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.446

H-Index - 226

eISSN - 1460-2350

pISSN - 0268-1161

DOI - 10.1093/humrep/dep019

Subject(s) - polycystic ovary , phosphatidylinositol , ovary , gene , medicine , biology , protein subunit , endocrinology , kinase , genetics , insulin resistance , insulin

Insulin resistance is a core feature of polycystic ovary syndrome (PCOS). Phosphatidylinositol (PI) 3-kinase is an important enzyme in the early insulin signaling cascade and plays a key role in insulin-mediated glucose transport. In its regulatory subunit, p85alpha, there is a common amino acid substitution (the Met326Ile polymorphism), and this amino acid may be crucial for the function of the p85alpha regulatory subunit and PI3-kinase.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research