A novel embryonic stem cell line derived from the common marmoset monkey (Callithrix jacchus) exhibiting germ cell-like characteristics | Zendy

Thomas Müller | Zendy; Gerhard Fleischmann | Zendy; Katja Eildermann | Zendy; Kerstin MätzRensing | Zendy; Peter A. Horn | Zendy; Emi Sasaki | Zendy; R. Behr | Zendy

Open Access

A novel embryonic stem cell line derived from the common marmoset monkey (Callithrix jacchus) exhibiting germ cell-like characteristics

Author(s) -

Thomas Müller,

Gerhard Fleischmann,

Katja Eildermann,

Kerstin MätzRensing,

Peter A. Horn,

Emi Sasaki,

R. Behr

Publication year - 2009

Publication title -

human reproduction

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.446

H-Index - 226

eISSN - 1460-2350

pISSN - 0268-1161

DOI - 10.1093/humrep/dep012

Subject(s) - embryoid body , biology , homeobox protein nanog , sox2 , callithrix , embryonic stem cell , induced pluripotent stem cell , marmoset , stem cell , cellular differentiation , germ cell , microbiology and biotechnology , kosr , immunology , genetics , paleontology , gene

Embryonic stem cells (ESC) hold great promise for the treatment of degenerative diseases. However, before clinical application of ESC in cell replacement therapy can be achieved, the safety and feasibility must be extensively tested in animal models. The common marmoset monkey (Callithrix jacchus) is a useful preclinical non-human primate model due to its physiological similarities to human. Yet, few marmoset ESC lines exist and differences in their developmental potential remain unclear.

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