Preimplantation genetic screening outcomes are associated with culture conditions | Zendy

Claire E. Beyer | Zendy; Tiki Osianlis | Zendy; Kym Boekel | Zendy; Elissa Osborne | Zendy; Luk Rombauts | Zendy; James Catt | Zendy; V. Kralevski | Zendy; Bibi Shahnaz Aali | Zendy; Lyn Gras | Zendy

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Preimplantation genetic screening outcomes are associated with culture conditions

Author(s) -

Claire E. Beyer,

Tiki Osianlis,

Kym Boekel,

Elissa Osborne,

Luk Rombauts,

James Catt,

V. Kralevski,

Bibi Shahnaz Aali,

Lyn Gras

Publication year - 2009

Publication title -

human reproduction

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.446

H-Index - 226

eISSN - 1460-2350

pISSN - 0268-1161

DOI - 10.1093/humrep/den502

Subject(s) - aneuploidy , blastomere , in vitro fertilisation , embryo , biopsy , medicine , genetic testing , selection (genetic algorithm) , biology , andrology , gynecology , obstetrics , genetics , embryogenesis , chromosome , artificial intelligence , computer science , gene

Although preimplantation genetic screening (PGS) is widely offered, there are contradictory reports on the clinical merit of this procedure. Any gain from embryo selection following aneuploidy screening must significantly outweigh the impact of the procedure. Variability of technical expertise in embryo biopsy, blastomere fixation, fluorescence in situ hybridization analysis, along with suboptimal laboratory quality control and inappropriate patient selection may impact PGS outcomes.

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