In vitro testing of rationally designed spermicides for selectively targeting human sperm in vagina to ensure safe contraception† | Zendy

Rajeev Jain | Zendy; Ashish Jain | Zendy; Jagdamba P. Maikhuri | Zendy; Vishnu Sharma | Zendy; Anil Kumar Dwivedi | Zendy; Santosh Kumar | Zendy; Kalyan Mitra | Zendy; Virendra K. Bajpai | Zendy; Gopal Gupta | Zendy

Open Access

In vitro testing of rationally designed spermicides for selectively targeting human sperm in vagina to ensure safe contraception†

Author(s) -

Rajeev Jain,

Ashish Jain,

Jagdamba P. Maikhuri,

Vishnu Sharma,

Anil Kumar Dwivedi,

Santosh Kumar,

Kalyan Mitra,

Virendra K. Bajpai,

Gopal Gupta

Publication year - 2008

Publication title -

human reproduction

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.446

H-Index - 226

eISSN - 1460-2350

pISSN - 0268-1161

DOI - 10.1093/humrep/den415

Subject(s) - spermicide , vagina , sperm , hela , in vitro , andrology , chemistry , pharmacology , gynecology , biology , medicine , family planning , biochemistry , research methodology , genetics , population , environmental health

Rational synthesis of novel structures resulted in two unique molecules (DSE-36 and DSE-37, disulphide esters of carbothioic acid) that killed sperm 25 times more strongly and with a precisely targeted action than nonoxynol-9 (N-9). We examine the effects of DSE-36 and DSE-37 on human spermatozoa versus HeLa cells to establish specificity and safety compared with N-9.

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