Induction of ovulation by a potent, orally active, low molecular weight agonist (Org 43553) of the luteinizing hormone receptor | Zendy

Ruud van de Lagemaat | Zendy; C. Marco Timmers | Zendy; J. Kelder | Zendy; C. van Koppen | Zendy; Sietse Mosselman | Zendy; Rob Hanssen | Zendy

Open Access

Induction of ovulation by a potent, orally active, low molecular weight agonist (Org 43553) of the luteinizing hormone receptor

Author(s) -

Ruud van de Lagemaat,

C. Marco Timmers,

J. Kelder,

C. van Koppen,

Sietse Mosselman,

Rob Hanssen

Publication year - 2008

Publication title -

human reproduction

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.446

H-Index - 226

eISSN - 1460-2350

pISSN - 0268-1161

DOI - 10.1093/humrep/den412

Subject(s) - ovulation , luteinizing hormone , agonist , endocrinology , medicine , ovulation induction , human chorionic gonadotropin , oral administration , in vivo , testosterone (patch) , pharmacokinetics , biology , hormone , pharmacology , receptor , microbiology and biotechnology

In assisted reproductive technology, human chorionic gonadotrophin (hCG) is administered subcutaneously for the induction of oocyte maturation and ovulation. Our efforts to develop orally bioavailable luteinizing hormone (LH) receptor agonists have led to the discovery of Org 43553, a low molecular weight (LMW) LH receptor (LH-R) agonist.

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