Sex-specific differences in fetal germ cell apoptosis induced by ionizing radiation | Zendy

Marie-Justine Guerquin | Zendy; Clotilde Duquenne | Zendy; H. Coffigny | Zendy; Virginie RouillerFabre | Zendy; Romain Lambrot | Zendy; Mariana Bakalska | Zendy; R. Frydman | Zendy; R. Habert | Zendy; Gabriel Livera | Zendy

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Sex-specific differences in fetal germ cell apoptosis induced by ionizing radiation

Author(s) -

Marie-Justine Guerquin,

Clotilde Duquenne,

H. Coffigny,

Virginie RouillerFabre,

Romain Lambrot,

Mariana Bakalska,

R. Frydman,

R. Habert,

Gabriel Livera

Publication year - 2008

Publication title -

human reproduction

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.446

H-Index - 226

eISSN - 1460-2350

pISSN - 0268-1161

DOI - 10.1093/humrep/den410

Subject(s) - ionizing radiation , apoptosis , germ cell , andrology , germ , fetus , biology , medicine , pregnancy , genetics , microbiology and biotechnology , irradiation , physics , gene , nuclear physics

We have previously shown that male human fetal germ cells are highly radiosensitive and that their death depends on p53 activation. Male germ cell apoptosis was initiated with doses as low as 0.1 Gy and was prevented by pifithrin alpha, a p53 inhibitor. In this study, we investigated the radiosensitivity of early female and male fetal proliferating germ cells.

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