Localization of matrix metalloproteinase (MMP)-2, MMP-9 and tissue inhibitors for MMPs (TIMPs) in uterine natural killer cells in early human pregnancy | Zendy

Katsuhiko Naruse | Zendy; Gendie E. Lash | Zendy; BA Innes | Zendy; HA Otun | Zendy; R.F. Searle | Zendy; S. C. Robson | Zendy; JUDITH BULMER | Zendy

Open Access

Localization of matrix metalloproteinase (MMP)-2, MMP-9 and tissue inhibitors for MMPs (TIMPs) in uterine natural killer cells in early human pregnancy

Author(s) -

Katsuhiko Naruse,

Gendie E. Lash,

BA Innes,

HA Otun,

R.F. Searle,

S. C. Robson,

JUDITH BULMER

Publication year - 2008

Publication title -

human reproduction

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.446

H-Index - 226

eISSN - 1460-2350

pISSN - 0268-1161

DOI - 10.1093/humrep/den408

Subject(s) - placentation , decidua , matrix metalloproteinase , spiral artery , trophoblast , myometrium , biology , metalloproteinase , microbiology and biotechnology , secretion , pregnancy , endocrinology , regulator , tissue inhibitor of metalloproteinase , medicine , uterus , placenta , fetus , biochemistry , genetics , gene

Invasion by extravillous trophoblast into uterine decidua and myometrium with remodeling of spiral arteries is essential for normal human pregnancy and is tightly regulated. Uterine natural killer (uNK) cells appear to be a major maternal regulator of placentation through the secretion of growth factors, cytokines and proteinases.

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