Assessment of the developmental competence of human somatic cell nuclear transfer embryos by oocyte morphology classification | Zendy

Yang Yu | Zendy; Qingyun Mai | Zendy; Xiaoqi Chen | Zendy; Leyun Wang | Zendy; Ling Gao | Zendy; Canquan Zhou | Zendy; Qi Zhou | Zendy

Open Access

Assessment of the developmental competence of human somatic cell nuclear transfer embryos by oocyte morphology classification

Author(s) -

Yang Yu,

Qingyun Mai,

Xiaoqi Chen,

Leyun Wang,

Ling Gao,

Canquan Zhou,

Qi Zhou

Publication year - 2008

Publication title -

human reproduction

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.446

H-Index - 226

eISSN - 1460-2350

pISSN - 0268-1161

DOI - 10.1093/humrep/den407

Subject(s) - oocyte , somatic cell nuclear transfer , biology , reprogramming , perivitelline space , embryo , blastocyst , andrology , embryogenesis , somatic cell , microbiology and biotechnology , genetics , cell , zona pellucida , gene , medicine

The oocyte plays a key role in reprogramming the epigenetic status of donor cell nuclei, and the absence of reprogramming elements in the cytoplasm or aberrant accumulation of proteins can trigger the abnormal development of nuclear transfer (NT) embryos. Previous studies have demonstrated the relationship between oocyte morphology and both embryo development and pregnancy outcome. In the present study, we compared the morphology of oocytes with subsequent development of human somatic cell NT (SCNT) embryos.

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