Tunicamycin enhances the apoptosis induced by tumor necrosis factor-related apoptosis-inducing ligand in endometriotic stromal cells | Zendy

A. Hasegawa | Zendy; Yutaka Osuga | Zendy; Yasushi Hirota | Zendy; Koji Hamasaki | Zendy; A. Kodama | Zendy; Mutsuo Harada | Zendy; T. Tajima | Zendy; Y. Takemura | Zendy; Tetsuya Hirata | Zendy; Osamu Yoshino | Zendy; Kaori Koga | Zendy; T. Yano | Zendy; Yojiro Taketani | Zendy

Open Access

Tunicamycin enhances the apoptosis induced by tumor necrosis factor-related apoptosis-inducing ligand in endometriotic stromal cells

Author(s) -

A. Hasegawa,

Yutaka Osuga,

Yasushi Hirota,

Koji Hamasaki,

A. Kodama,

Mutsuo Harada,

T. Tajima,

Y. Takemura,

Tetsuya Hirata,

Osamu Yoshino,

Kaori Koga,

T. Yano,

Yojiro Taketani

Publication year - 2008

Publication title -

human reproduction

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.446

H-Index - 226

eISSN - 1460-2350

pISSN - 0268-1161

DOI - 10.1093/humrep/den385

Subject(s) - apoptosis , stromal cell , tumor necrosis factor alpha , cancer research , necrosis , endometriosis , osteoprotegerin , tunicamycin , biology , endocrinology , medicine , chemistry , receptor , activator (genetics) , biochemistry , unfolded protein response

The increase in concentration of osteoprotegerin, an antagonist of tumor necrosis factor-related apoptosis-inducing ligand (TRAIL), in the peritoneal fluid of women with endometriosis may interfere with TRAIL-induced apoptosis in endometriotic cells and promote the development of endometriosis. In the present study, the effect of tunicamycin, a possible apoptosis enhancer, on TRAIL-induced apoptosis in endometriotic stromal cells (ESC) was determined.

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