Open AccessPeritoneal macrophage depletion by liposomal bisphosphonate attenuates endometriosis in the rat model
Author(s) -
Elran Haber,
Haim Danenberg,
Nickolay Koroukhov,
R. Ron-El,
Gershon Golomb,
M. Schachter
Publication year - 2008
Publication title -
human reproduction
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.446
H-Index - 226
eISSN - 1460-2350
pISSN - 0268-1161
DOI - 10.1093/humrep/den375
Subject(s) - endometriosis , macrophage , medicine , liposome , rat model , pharmacology , endocrinology , andrology , chemistry , biochemistry , in vitro
Activation of macrophages is central to the implantation of endometriosis (EM). We examined the hypothesis that macrophage depletion by intraperitoneal (IP) injection of liposomal alendronate (LA) could result in EM attenuation in a rat model, thus supporting the notion of the pivotal role of macrophages in EM pathology.
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