A reduced oxygen tension (5%) is not beneficial for maintaining human embryonic stem cells in the undifferentiated state with short splitting intervals | Zendy

HsinFu Chen | Zendy; HungChih Kuo | Zendy; Wei Chen | Zendy; Fei-Hua Wu | Zendy; YuShih Yang | Zendy; HongNerng Ho | Zendy

Open Access

A reduced oxygen tension (5%) is not beneficial for maintaining human embryonic stem cells in the undifferentiated state with short splitting intervals

Author(s) -

HsinFu Chen,

HungChih Kuo,

Wei Chen,

Fei-Hua Wu,

YuShih Yang,

HongNerng Ho

Publication year - 2008

Publication title -

human reproduction

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.446

H-Index - 226

eISSN - 1460-2350

pISSN - 0268-1161

DOI - 10.1093/humrep/den345

Subject(s) - oxygen tension , biology , homeobox protein nanog , embryonic stem cell , wnt signaling pathway , desmin , microbiology and biotechnology , andrology , stem cell , gene , chemistry , immunology , oxygen , genetics , immunohistochemistry , signal transduction , vimentin , medicine , organic chemistry , induced pluripotent stem cell

Human embryos grow naturally in vivo in lower oxygen (O(2)) tension environments than atmospheric O(2) tension. Therefore, human embryonic stem cells (hESC), a derivative of embryos, will likely grow more favorably in a reduced O(2) tension. This study aimed to compare the behavior of hESC under reduced O(2) tension (5%) versus normoxia (21%).

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