A potential tolerogenic immune mechanism in a trophoblast cell line through the activation of chemokine-induced T cell death and regulatory T cell modulation | Zendy

Laura Fraccaroli | Zendy; Joanne Alfieri | Zendy; Luciana Larocca | Zendy; Mario Calafat | Zendy; Gil Mor | Zendy; Claudia Pérez Leirós | Zendy; Rosanna Ramhorst | Zendy

Open Access

A potential tolerogenic immune mechanism in a trophoblast cell line through the activation of chemokine-induced T cell death and regulatory T cell modulation

Author(s) -

Laura Fraccaroli,

Joanne Alfieri,

Luciana Larocca,

Mario Calafat,

Gil Mor,

Claudia Pérez Leirós,

Rosanna Ramhorst

Publication year - 2008

Publication title -

human reproduction

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.446

H-Index - 226

eISSN - 1460-2350

pISSN - 0268-1161

DOI - 10.1093/humrep/den344

Subject(s) - trophoblast , biology , foxp3 , t cell , immunology , peripheral blood mononuclear cell , chemokine , immune system , microbiology and biotechnology , andrology , placenta , medicine , fetus , pregnancy , biochemistry , in vitro , genetics

Successful implantation is followed by a local pro-inflammatory and Th1 response, subsequently controlled by Th2. Regulated upon activation, normal T cell expressed and secreted (RANTES) promotes a Th1 response and is implicated as a physiologic tolerogenic factor; therefore, we studied its potential role in the trophoblast-maternal leukocyte dialog.

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