Open AccessFEM1A and FEM1B: novel candidate genes for polycystic ovary syndrome
Author(s) -
Mark O. Goodarzi,
Joseph Maher,
Jinrui Cui,
Xiuqing Guo,
Kent D. Taylor,
Ricardo Azziz
Publication year - 2008
Publication title -
human reproduction
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.446
H-Index - 226
eISSN - 1460-2350
pISSN - 0268-1161
DOI - 10.1093/humrep/den324
Subject(s) - polycystic ovary , candidate gene , gene , ovary , biology , genetics , endocrinology , medicine , insulin , insulin resistance
Human homologs (FEM1A, FEM1B, FEM1C) of nematode sex determination genes are candidate genes for polycystic ovary syndrome (PCOS). We previously identified a FEM1A mutation (H500Y) in a woman with PCOS; FEM1B has been implicated in insulin secretion.
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