Long-term spermatogonial survival in cryopreserved and xenografted immature human testicular tissue | Zendy

Christine Wyns | Zendy; Anne Van Langendonckt | Zendy; F.X. Wese | Zendy; J. Donnez | Zendy; Mara Curaba | Zendy

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Long-term spermatogonial survival in cryopreserved and xenografted immature human testicular tissue

Author(s) -

Christine Wyns,

Anne Van Langendonckt,

F.X. Wese,

J. Donnez,

Mara Curaba

Publication year - 2008

Publication title -

human reproduction

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.446

H-Index - 226

eISSN - 1460-2350

pISSN - 0268-1161

DOI - 10.1093/humrep/den272

Subject(s) - andrology , biology , spermatogenesis , immunostaining , cryopreservation , histology , transplantation , germ cell , spermatid , testicular sperm extraction , immunohistochemistry , immunology , endocrinology , embryo , intracytoplasmic sperm injection , medicine , microbiology and biotechnology , genetics , gene , in vitro fertilisation

Preservation of the male germ line in prepubertal boys undergoing gonadotoxic treatment is a crucial consideration in terms of their future quality of life. As these patients do not yet produce spermatozoa for freezing, only immature tissue is available for storage. We studied the survival, proliferation and differentiation capacity of spermatogonia after cryopreservation and long-term transplantation of immature testicular tissue pieces.

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