Glycan stem-cell markers are specifically expressed by spermatogonia in the adult non-human primate testis | Zendy

Thomas Müller | Zendy; Katja Eildermann | Zendy; Rajiv Dhir | Zendy; Stefan Schlatt | Zendy; Rüdiger Behr | Zendy

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Glycan stem-cell markers are specifically expressed by spermatogonia in the adult non-human primate testis

Author(s) -

Thomas Müller,

Katja Eildermann,

Rajiv Dhir,

Stefan Schlatt,

Rüdiger Behr

Publication year - 2008

Publication title -

human reproduction

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.446

H-Index - 226

eISSN - 1460-2350

pISSN - 0268-1161

DOI - 10.1093/humrep/den253

Subject(s) - induced pluripotent stem cell , biology , embryonic stem cell , kosr , stem cell , microbiology and biotechnology , p19 cell , cellular differentiation , adult stem cell , embryoid body , embryonal carcinoma , antigen , immunology , genetics , gene

The glycan cell surface molecules, stage-specific embryonic antigen (SSEA)-1, -3 and -4 and tumor-rejection antigen (TRA)-1-60 and -1-81, are expressed in specific combinations by undifferentiated pluripotent cells, i.e. embryonic stem cells, induced pluripotent stem cells, embryonal carcinoma cells, primordial germ cells and embryonic germ cells. Upon differentiation of the cells, these markers vanish. Recently, it has been shown that also neonatal and adult mouse testes contain pluripotent cells. Here, we aimed at identifying in situ possibly pluripotent cells in the adult primate testis.

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