The oocyte population is not renewed in transplanted or irradiated adult ovaries | Zendy

S. Rizwana Begum | Zendy; Virginia E. Papaioannou | Zendy; Roger G. Gosden | Zendy

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The oocyte population is not renewed in transplanted or irradiated adult ovaries

Author(s) -

S. Rizwana Begum,

Virginia E. Papaioannou,

Roger G. Gosden

Publication year - 2008

Publication title -

human reproduction

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.446

H-Index - 226

eISSN - 1460-2350

pISSN - 0268-1161

DOI - 10.1093/humrep/den249

Subject(s) - oocyte , andrology , population , ovary , biology , gynecology , medicine , endocrinology , microbiology and biotechnology , embryo , environmental health

According to conventional theory, the oocyte population is not renewed in mammalian ovaries after birth. A new hypothesis proposes that oocytes are generated continuously from haematopoietic progenitor cells. There is, however, no evidence that they can ovulate, although they may partially restore fertility by organizing 'helper follicles'. The hypothesis that follicles can form de novo in adult ovaries has been tested in a transplant model.

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