No beneficial effect of preimplantation genetic screening in women of advanced maternal age with a high risk for embryonic aneuploidy | Zendy

Moniek Twisk | Zendy; Sebastiaan Mastenbroek | Zendy; Annemieke Hoek | Zendy; M. J. Heineman | Zendy; F. van der Veen | Zendy; Peter Bossuyt | Zendy; Sjoerd Repping | Zendy; Johanna C. Korevaar | Zendy

Open Access

No beneficial effect of preimplantation genetic screening in women of advanced maternal age with a high risk for embryonic aneuploidy

Author(s) -

Moniek Twisk,

Sebastiaan Mastenbroek,

Annemieke Hoek,

M. J. Heineman,

F. van der Veen,

Peter Bossuyt,

Sjoerd Repping,

Johanna C. Korevaar

Publication year - 2008

Publication title -

human reproduction

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.446

H-Index - 226

eISSN - 1460-2350

pISSN - 0268-1161

DOI - 10.1093/humrep/den231

Subject(s) - aneuploidy , intracytoplasmic sperm injection , in vitro fertilisation , advanced maternal age , live birth , biology , andrology , preimplantation genetic diagnosis , obstetrics , gynecology , medicine , chromosome , embryo , pregnancy , genetics , fetus , gene

Human preimplantation embryos generated through in vitro fertilization (IVF) or intracytoplasmic sperm injection (ICSI) treatments show a variable rate of numerical chromosome abnormalities or aneuploidies. Preimplantation genetic screening (PGS) has been designed to screen for aneuploidies in high risk patients, with the aim of improving live birth rates in IVF/ICSI. We assessed whether the effect of PGS on live births rates differs in women of advanced maternal age with variable risks for embryonic aneuploidy, and weighed these effects against the results obtained after IVF/ICSI without PGS.

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