Hypoxia is responsible for soluble vascular endothelial growth factor receptor-1 (VEGFR-1) but not for soluble endoglin induction in villous trophoblast | Zendy

Carine Munaut | Zendy; Sophie Lorquet | Zendy; Christel Péqueux | Zendy; S. Blacher | Zendy; Sarah Berndt | Zendy; Françis Frankenne | Zendy; JeanMichel Foidart | Zendy

Open Access

Hypoxia is responsible for soluble vascular endothelial growth factor receptor-1 (VEGFR-1) but not for soluble endoglin induction in villous trophoblast

Author(s) -

Carine Munaut,

Sophie Lorquet,

Christel Péqueux,

S. Blacher,

Sarah Berndt,

Françis Frankenne,

JeanMichel Foidart

Publication year - 2008

Publication title -

human reproduction

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.446

H-Index - 226

eISSN - 1460-2350

pISSN - 0268-1161

DOI - 10.1093/humrep/den114

Subject(s) - vascular endothelial growth factor , placental growth factor , endoglin , angiogenesis , trophoblast , medicine , endocrinology , hypoxia (environmental) , placenta , biology , vascular endothelial growth factor a , kinase insert domain receptor , andrology , soluble fms like tyrosine kinase 1 , chemistry , fetus , microbiology and biotechnology , vegf receptors , pregnancy , genetics , stem cell , organic chemistry , oxygen , cd34

Pre-eclampsia is a pregnancy disorder characterized by a maternal endothelial cell dysfunction associated with low levels of circulating placental growth factor (PlGF) and increased levels of total vascular endothelial growth factor (VEGF), soluble VEGF receptor-1 (sVEGFR-1), and soluble endoglin, a transforming growth factor beta1 and 3 coreceptor. Here, we tested the hypothesis that these altered levels of angiogenic cytokines and of the anti-angiogenic soluble forms of cytokine receptors could be the consequence of hypoxia.

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