A low concentration of genistein induces estrogen receptor-alpha and insulin-like growth factor-I receptor interactions and proliferation in uterine leiomyoma cells | Zendy

Xudong Di | Zendy; Linda ChiaHui Yu | Zendy; Alicia B. Moore | Zendy; Lisandra Castro | Zendy; Xiaolin Zheng | Zendy; Tonia Hermon | Zendy; Darlene Dixon | Zendy

Open Access

A low concentration of genistein induces estrogen receptor-alpha and insulin-like growth factor-I receptor interactions and proliferation in uterine leiomyoma cells

Author(s) -

Xudong Di,

Linda ChiaHui Yu,

Alicia B. Moore,

Lisandra Castro,

Xiaolin Zheng,

Tonia Hermon,

Darlene Dixon

Publication year - 2008

Publication title -

human reproduction

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.446

H-Index - 226

eISSN - 1460-2350

pISSN - 0268-1161

DOI - 10.1093/humrep/den087

Subject(s) - genistein , mapk/erk pathway , estrogen receptor , endocrinology , estrogen receptor alpha , medicine , transactivation , biology , insulin like growth factor , estrogen receptor beta , protein kinase a , mek inhibitor , cell growth , growth factor , kinase , chemistry , receptor , microbiology and biotechnology , gene expression , biochemistry , cancer , gene , breast cancer

Previously, we found that genistein at low concentrations stimulates the growth of human uterine leiomyoma (LM) cells, but not uterine smooth muscle (myometrial) cells (SMC). The aim of this study was to understand the molecular mechanism whereby genistein causes hyperproliferation of LM cells.

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