Characterization of sperm chromatin quality in testicular cancer and Hodgkin's lymphoma patients prior to chemotherapy | Zendy

Cristián O’Flaherty | Zendy; Farida Vaisheva | Zendy; Barbara F. Hales | Zendy; Peter Chan | Zendy; Bernard Robaire | Zendy

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Characterization of sperm chromatin quality in testicular cancer and Hodgkin's lymphoma patients prior to chemotherapy

Author(s) -

Cristián O’Flaherty,

Farida Vaisheva,

Barbara F. Hales,

Peter Chan,

Bernard Robaire

Publication year - 2008

Publication title -

human reproduction

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.446

H-Index - 226

eISSN - 1460-2350

pISSN - 0268-1161

DOI - 10.1093/humrep/den081

Subject(s) - sperm , testicular cancer , terminal deoxynucleotidyl transferase , cancer , biology , chromatin , dna damage , cancer research , comet assay , tunel assay , andrology , pathology , immunology , medicine , dna , genetics , immunohistochemistry

Although the incidences of testicular cancer and Hodgkin's lymphoma have increased in young men over the past decade, combination chemotherapy has improved survival. As fertility is of importance to these patients, characterization of sperm chromatin structure is needed. We assessed sperm chromatin in testicular cancer and Hodgkin's lymphoma patients prior to chemotherapy, in comparison with control community and idiopathic infertile volunteers.

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