Small glutamine-rich tetratricopeptide repeat-containing protein alpha (SGTA), a candidate gene for polycystic ovary syndrome | Zendy

Mark O. Goodarzi | Zendy; Ning Xu | Zendy; Jinrui Cui | Zendy; Xiuqing Guo | Zendy; Y.I. Chen | Zendy; Ricardo Azziz | Zendy

Open Access

Small glutamine-rich tetratricopeptide repeat-containing protein alpha (SGTA), a candidate gene for polycystic ovary syndrome

Author(s) -

Mark O. Goodarzi,

Ning Xu,

Jinrui Cui,

Xiuqing Guo,

Y.I. Chen,

Ricardo Azziz

Publication year - 2008

Publication title -

human reproduction

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.446

H-Index - 226

eISSN - 1460-2350

pISSN - 0268-1161

DOI - 10.1093/humrep/den065

Subject(s) - polycystic ovary , haplotype , biology , single nucleotide polymorphism , allele , endocrinology , androgen , androgen receptor , genetics , tetratricopeptide , medicine , snp , hyperandrogenism , candidate gene , insulin resistance , insulin , gene , genotype , prostate cancer , hormone , cancer

Polycystic ovary syndrome (PCOS) is a heterogenic, complex common genetic disease. Multiple pathways are involved in its pathogenesis, including the androgen signaling pathway and insulin signaling pathway. Small glutamine-rich tetratricopeptide repeat-containing protein alpha (SGTA) is a putative member of the androgen receptor-chaperone-co-chaperone complex, and may play a role in androgen signaling as a co-chaperone. Polymorphisms in the SGTA gene have not been evaluated for a role in PCOS.

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